Celine Dion's Struggle for a Second Baby

Céline Dion

After four unsuccessful rounds of in vitro fertilization, Céline Dion is not giving up hope for a second child, she tells PEOPLE in an exclusive cover story.

"I'm going to try until it works," says Dion, 41, who has been giving herself daily hormone shots – and enduring the roller-coaster ride of emotions they bring – after the heartbreaking loss of a pregnancy in August and three other failed IVF attempts last fall.

"Five's my lucky number," she adds, "so this is the time it's got to [work]."

While her husband/manager Rene Angélil, 68, says they "go crazy" waiting for the results after each try, Dion – whose new concert film and family documentary Céline: Through the Eyes of the World, will be released Feb. 17 – stays positive, focusing her energies on son Rene-Charles, 9, who is thriving as a second-grader at his new school in Florida.

For more on Dion's hopes for another baby, life as a soccer mom, and her upcoming return to the stage, pick up the new issue of PEOPLE, on newsstands Friday